The President said on Twitter: “Tremendous success tonight. Thank you to all!”
Republicans will keep control of the Senate but the House is likely to be won by the Democrats.
Trump previously claimed responsibility for the outcome of the midterm elections, with a White House statement saying the he gave voters a “clear choice”.
Americans are voting for all 435 seats in the House and 35 out of 100 seats in the Senate, a as well as state governors.
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The President, who is known for his unique Twitter presence, had been silent since results became to emerge.
It is common for the midterms to go poorly for the party with an incumbent President, but losing the House will still come as a huge blow to Trump, after campaigning relentlessly over the past couple of months.
Trump has headlined 30 rallies in two months and packed out arenas of adoring fans.
However, with a voter turnout surge and a disapproval rating for the President sitting at 55 percent, his opponents have come to the ballot box to make their voices heard.
A number of other politicians have also responded to the results, giving their verdict on the night.
Ted Cruz, who was re-elected as a Texas governor, said: “Thank you, Texas!
“Now let’s get back to work to defend jobs, freedom and security for Texas and America.”
Vice President Mike Pence congratulated his brother for serving in the US Congress.
He said: “Congrats to my brother Greg Pence on being elected to serve in the US Congress.
“Greg served our country admirably in uniform and will do the same in Washington DC”
Minority Leader of the House and potential next Speaker Nancy Pelosi gave a speech that exuded confidence of success for the Democrats after her party were projected to take control of the chamber.
She said: “When Democrats win and we will win tonight, we will have a Congress that is open, transparent and accountable to American people.
“We’ll strive for bipartisanship, seeking common ground as we are responsible to do.
“But when we can’t find that common ground, we will stand our ground.”